SPHK2 Antibody (N-term)

Synthetic Peptide

Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.

Polyclonal

56848

Purified Rabbit Polyclonal Antibody (Pab)

SPHK2 Antibody (P15) (Cat. #AP7238a) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the SPHK2 antibody detected the SPHK2 protein (arrow).

1:1000

IHC-P

Rabbit Ig

1-30

This SPHK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SPHK2.