SPHK2 Antibody (C-term)

Primary Antibodies; Cancer; Cell Biology; Metabolism; Signal Transduction; Catalog Updated; Fc gamma R-mediated phagocytosis; Lysosome

Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY72.

RB03625

Purified Rabbit Polyclonal Antibody (Pab)

69217

590-620

WB: 1:1000
WB: 1:1000
IHC-P-Leica: 1:250
IHC-P-Leica: 1:250