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CD163 Antibody (N-term)

CD163 Antibody (N-term)

Item no.	ABC-AP7330a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor, CD163, Soluble CD163, sCD163, CD163, M130
Available
Primary Accession	Q86VB7
Antigen Type	Synthetic Peptide
Bio Background	CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
Bio References	Buehler, P.W., Abraham, B. Blood 113 (11), 2578-2586 (2009) Fabriek, B.O., van Bruggen, R. Blood 113 (4), 887-892 (2009) Strauss, M. and Levy, A.P. Mol. Cell. Biochem. 317 (1-2), 131-135 (2008) Groselj-Grenc, M., Ihan, A. Mediators Inflamm. 2008, 202646 (2008)
Gene ID	9332
Gene Name	CD163
Reactivity	H
Calculated MW	125451
Antigen Region	245-274
Antigen Source	HUMAN
Target/Specificity	This CD163 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human CD163.
NCBI Accession	NP_004235.4; NP_981961.2

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Amount: 80 ul

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