DYRK1A Antibody (N-term)

Synthetic Peptide

DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.

Polyclonal

1859

Purified Rabbit Polyclonal Antibody (Pab)

All lanes : Anti-DYRK1A Antibody (N-term) at 1:500-1:2000 dilution
Lane 1: Hela whole cell lysate
Lane 2: PC-3 whole cell lysate
Lane 3: SH-SY5Y whole cell lysate


Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 86 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

1:500-1:2000

IHC-P

Q2TAE3; Q63470; Q61214

Rabbit Ig

107-136

This DYRK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.