Aromatase (CYP19A1) Antibody (C-term)

Synthetic Peptide

CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in the gene encoding CYP19A1 can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.

Polyclonal

1588

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of anti-CYP19A1 Pab (Cat.#AP7571b) in Jurkat cell line lysates (35ug/lane).CYP19A1 (arrow) was detected using the purified Pab.

1:1000

WB

Formalin-fixed and paraffin-embedded human placenta tissue reacted with CYP19A1 antibody (C-term) (Cat.#AP7571b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

1:10~50

57883

HUMAN

NP_000094.2; NP_112503.1