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CYP3A4 Antibody (Center)

CYP3A4 Antibody (Center)

Item no.	ABC-AP7788c-ev-50ul
Manufacturer	Abcepta
Amount	50 ul
Category	Antibodies Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Flow cytometry, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cytochrome P450 3A4, 11413-,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Nifedipine oxidase, Quinine 3-monooxy
Available
Primary Accession	P08684
Antigen Type	Synthetic Peptide
Bio Background	CYP3A4, is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens.
Bio References	Sandanaraj, E., Clin. Cancer Res. 14 (21), 7116-7126 (2008) Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004) Inoue, K., Jpn. J. Hum. Genet. 37 (2), 133-138 (1992)
Gene ID	1576
Gene Name	CYP3A4 {ECO:0000303\|PubMed:11470997, ECO:0000312\|HGNC:HGNC:2637}
Reactivity	H
Calculated MW	57343
Antigen Region	228-255
Antigen Source	HUMAN
Target/Specificity	This CYP3A4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-255 amino acids from the Central region of human CYP3A4.
NCBI Accession	NP_001189784.1; NP_059488.2

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Amount: 50 ul

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