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TBK1 Antibody (S172)

TBK1 Antibody (S172)

Item no.	ABC-AP7887a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1, TBK1, NAK
Available
Primary Accession	Q9UHD2
Other Accession	Q6DFJ6; Q9WUN2; NP_037386; Q1JPV3
Antigen Type	Synthetic Peptide
Bio Background	The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
Bio References	Deng, W., J. Biol. Chem. 283 (51), 35590-35597 (2008) Chessler, A.D., J. Immunol. 181 (11), 7917-7924 (2008) Soulat, D., EMBO J. 27 (15), 2135-2146 (2008)
Gene ID	29110
Gene Name	TBK1 {ECO:0000303\|PubMed:10581243, ECO:0000312\|HGNC:HGNC:11584}
Reactivity	H, M
Predicted	Zf, X
Calculated MW	83642
Antigen Region	150-181
Antigen Source	HUMAN
Target/Specificity	This TBK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-181 amino acids from human TBK.
NCBI Accession	NP_037386.1

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Amount: 80 ul

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