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COT (MAP3K8/MEKK8) Antibody (C-term)

COT (MAP3K8/MEKK8) Antibody (C-term)

Item no.	ABC-AP7957b-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Antibodies Melanoma Immunohistochemistry Western Blot Primary Antibodies Thyroid Cancer
Type	Antibody Polyclonal
Applications	Western Blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Mitogen-activated protein kinase kinase kinase 8, Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2, TPL-2, MAP3K8, COT, ESTF
Available
Primary Accession	P41279
Other Accession	Q63562; Q07174
Antigen Type	Synthetic Peptide
Bio Background	COT, a member of the MAPKKK subfamily of Ser/Thr protein kinases, is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. It plays a role in the cell cycle. The longer form of cot has some transforming activity, although it is much weaker than the activated cot oncoprotein. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.
Bio References	Sanchez-Gongora, E., et al., J. Biol. Chem. 275(40):31379-31386 (2000). Aoki, M., et al., J. Biol. Chem. 268(30):22723-22732 (1993). Chan, A.M., et al., Oncogene 8(5):1329-1333 (1993). Miyoshi, J., et al., Mol. Cell. Biol. 11(8):4088-4096 (1991). Aoki, M., et al., Oncogene 6(9):1515-1519 (1991).
Gene ID	1326
Gene Name	MAP3K8
Reactivity	H
Predicted	M, Rat
Calculated MW	52925
Antigen Region	368-397
Antigen Source	HUMAN
Target/Specificity	This COT (MAP3K8/MEKK8) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-397 amino acids from the C-terminal region of human COT (MAP3K8/MEKK8).
NCBI Accession	NP_001231063.1; NP_005195.2

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Amount: 80 ul

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