SLC8A1 Antibody (Center)

Synthetic Peptide

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) centration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

Polyclonal

6546

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of SLC8A1 Antibody (Center) (Cat. #AP8939c) in HL-60(lane 1), K562(lane 2) cell line lysates (35ug/lane). SLC8A1 (arrow) was detected using the purified Pab.

1:1000

IHC-P

SLC8A1 Antibody (Center) (Cat. #AP8939c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

1:10~50

B, Rat

108547

HUMAN

NP_001106271.1; NP_001106272.1; NP_001106273.1; NP_001239553.1; NP_066920.1