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SRC8 Antibody (N-term)

SRC8 Antibody (N-term)

Item no.	ABC-AP9247a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	CTTN, EMS1, Src substrate cortactin, Amplaxin, Oncogene EMS1
Available
Primary Accession	Q14247
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	SRC8 is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.
Bio References	Xu, X.Z., et.al, Mod. Pathol. 23 (2), 187-196 (2010) Saitoh, Y., et.al, Int. J. Oncol. 35 (6), 1277-1288 (2009)
Clonality	Polyclonal
Clone/Animal Names	RB24340
Gene ID	2017
Gene Name	CTTN
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of SRC8 Antibody (N-term) (Cat. #AP9247a) in HL-60 cell line lysates (35ug/lane). SRC8 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human breast carcinoma with SRC8 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	Q66HL2; Q60598; Q01406
Predicted	C, M, Rat
Isotype	Rabbit Ig
Calculated MW	61586
Antigen Region	9-38
Antigen Source	HUMAN
Target/Specificity	This SRC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human SRC8.
NCBI Accession	NP_001171669.1; NP_005222.2; NP_612632.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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