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LFNG Antibody (Center)

LFNG Antibody (Center)

Item no.	ABC-AP9524c-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Flow Cytometry Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Flow cytometry, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG
Available
Primary Accession	Q8NES3
Antigen Type	Synthetic Peptide
Bio Background	LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1, 3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150).
Bio References	Dunwoodie, S.L. Biochim. Biophys. Acta 1792(2):100-111(2009) Reedijk, M., et al. Int. J. Oncol. 33(6):1223-1229(2008) Sparrow, D.B., et al. Am. J. Hum. Genet. 78(1):28-37(2006) Cole, S.E., et al. Dev. Cell 3(1):75-84(2002) Moran, J.L., et al. Mamm. Genome 10(6):535-541(1999)
Gene ID	3955
Gene Name	LFNG
Reactivity	H
Calculated MW	41773
Antigen Region	86-114
Antigen Source	HUMAN
Target/Specificity	This LFNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human LFNG.
NCBI Accession	NP_001035257.1; NP_001035258.1; NP_001159827.1; NP_002295.1

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Amount: 80 ul

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