Caspase-9 Antibody

Caspase-9 antibody can be used for detection of caspase-9 by Western blot at 1:1000 dilution. A 46 kDa band should be detected.

CASP9; It has no cross response to other members in caspase family.

Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNF?, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

CASP9

46281

Caspase-9 Antibody is affinity chromatography purified via peptide column.

Caspase-9 antibody can be used for detection of caspase-9 by Western blot at 1:1000 dilution. A 46 kDa band should be detected.

Caspase-9 Antibody is supplied in PBS containing 0.02% sodium azide.