TCCR Antibody

Q6UWB1

TCCR Antibody: Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.

Polyclonal

IL27RA

Western blot analysis of TCCR expression in human spleen tissue lysate with TCCR antibody at 1 µg /ml.

Immunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 5 µg/mL.

Immunofluorescence of TCCR in Human Spleen cells with TCCR antibody at 20 µg/mL.

NP_004834; 4759328

69474

IL27RA;

TCCR antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

TCCR antibody can be used for detection of TCCR by Western blot at 1 µg/mL. An approximately 70 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.

TCCR Antibody is supplied in PBS containing 0.02% sodium azide.