ACE2 Antibody

ACE2; Anti-ACE2 has no cross response to ACE1.

ACE2 Antibody: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

ACE2

92463

ACE2 Antibody is affinity chromatography purified via peptide column.

ACE2 antibody can be used for the detection of ACE2 by Western blot at 0.5 to 2 µg/mL. A 90 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 2 µg/mL. For immunofluorescence start at 20 µg/mL.

ACE2 Antibody is supplied in PBS containing 0.02% sodium azide.