Caspase-1 Antibody

CASP1; Depending on cell lines or tissues used, other cleavage products may be observed.

Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1? and IL-18. Caspase-1 was initially identified as an IL-1?-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

CASP1

45159

Caspase-1 Antibody is affinity chromatography purified via peptide column.

Casp-1 antibody can be used for the detection of Caspase-1 by Western blot at 0.5 to 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.

Caspase-1 Antibody is supplied in PBS containing 0.02% sodium azide.