Bfl-1 Antibody

Q16548

Bfl-1 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells.

Polyclonal

BCL2A1

Immunofluorescence of Bcl 2 in mouse brain tissue with Bcl 2 Antibodyat 20 µg/mL.

NP_004040; 597

20132

Bfl-1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Bfl-1.

The immunogen is located within the last 50 amino acids of Bfl-1.

Bfl-1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Bfl-1 antibody can be used for the detection of Bfl-1 by Western blot at 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ g/mL. For immunofluorescence start at 20 μ g/mL.

Bfl-1 Antibody is supplied in PBS containing 0.02% sodium azide.