sRANK Ligand Antibody

TNFSF11;

sRANK Ligand Antibody: The receptor activator of NF-?B ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T cell-dependent immune response, lymph node organogenesis and bone formation. RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor. Activation of T cells, such as by treatment with interleukin-7, induces RANK-L production and leads to an increase of osteoclast formation and bone loss. Finally, sRANK-L can activate the antiapoptotic kinase Akt through a signaling complex involving Src kinase and TRAF6, suggesting sRANK-L may also play a role in regulating apoptosis. This antibody will recognize both the soluble form and the uncleaved transmembrane form of RANK-L.

TNFSF11

35478

sRANK Ligand Antibody is affinity chromatography purified via peptide column.

sRANK-L antibody can be used for detection of sRANK-L by Western blot at 0.25 - 0.5 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.

sRANK Ligand Antibody is supplied in PBS containing 0.02% sodium azide.