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Integrin alpha 4 Antibody

Integrin alpha 4 Antibody

Item no.	ABC-ASC10775
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Wegener KL and Campbell ID. Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions. Mol. Membr. Biol. 2008; 25:376-87. Kamata T, Puzon W, and Takada Y. Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29). Biochem J. 1995; 305:945-51. Berlin C, Berg EL, Briskin MJ, et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993; 74:185-95. Pulido R, Elices MJ, Campanero MR, et al. Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes. J. Biol. Chem. 1991; 266:10241-5.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Manufacturer - Category	Primary Antibodies; Immunology; Signal Transduction; Stem Cells; Integrin Antibodies
Manufacturer - Targets	ITGA4; At least two isoforms of integrin alpha 4 are known to exist.
Storage Conditions	Integrin alpha 4 antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	Integrin alpha 4 Antibody: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta1, the gut mucosal homing receptor for peripheral T cells.
Clonality	Polyclonal
Gene Name	ITGA4
Reactivity	H, M, Rat
Calculated Molecular Weight	114900
Antigen Source	Homo sapiens
Purification	Integrin alpha 4 Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	Integrin alpha 4 antibody can be used for the detection of Integrin alpha 4 by Western blot at 1 µg/mL. Antibody can also be used for immunoflourescence starting at 2 µg/mL.
Positive Control	;
Buffer	Integrin alpha 4 Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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