Comparison

KPNA2 Antibody

Item no. ABC-ASC11206
Manufacturer Abcepta
Amount 100 ug
Category
Type Antibody Primary
Applications WB, IF, ELISA, IHC-P
Specific against other
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Available
Primary Accession
P52292
Application
WB, IHC-P, IF, E
Bio Background
KPNA2 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA2 is the alpha subunit 2 of karyopherin, which forms a complex with importin subunit beta-1 and functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. It is ubiquitously expressed and contains an IBB/importin beta domain, ten Armadillo repeats that bind "cargo" and three intervening nuclear localization sequences (NLSs). It has recently been reported to play an important role in tumorigenesis and tumor progression.
Bio References
Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene Expr.1997; 7:61-72.
Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem.2003; 278: 51937-49.
Tseng SF, Chang CY, Wu KJ, et al. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. J. Biol. Chem.2005; 280:39594-600.
Sakai M, Sohda M, Miyazaki T, et al. Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma. Anticancer Res.2010; 30:851-6.
Clonality
Polyclonal
Gene ID
3838
Gene Name
KPNA2 (HGNC:6395)
Reactivity
H, M, Rat
Legend image 1
Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 antibody at (A) 1 and (B) 2 µg/mL.
Type image 1
WB
Legend image 2
Immunohistochemistry of KPNA2 in human heart tissue with KPNA2 antibody at 5 µg/mL.
Type image 2
IHC
Legend image 3
Immunofluorescence of KPNA2 in human heart tissue with KPNA2 antibody at 20 µg/mL.
Type image 3
IF
Other Accession
NP_002257; 4504897
Isotype
IgG
Calculated MW
57862
Antigen Source
Homo sapiens
Target/Specificity
KPNA2;
Purification
KPNA2 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage
KPNA2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form
Liquid
Application Notes
KPNA2 antibody can be used for detection of KPNA2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control
Rat Heart Tissue Lysate;
Buffer
KPNA2 Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

Delivery expected until 9/4/2025 

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