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LRRTM4 Antibody

LRRTM4 Antibody

Item no.	ABC-ASC11277
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IF, ELISA, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Primary Accession	Q86VH4
Application	WB, IHC-P, IF, E
Bio Background	LRRTM4 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Little is known about the function of LRRTM4; in mouse, it is expressed in the limb mesenchyme, neural tube, caudal mesoderm and in three distinct regions of the head. Later expression occurs in a subset of the developing sclerotome. Its similarity to other LRRTM family members suggests that LRRTM4 may also play a role in the development and maintenance of the vertebrate nervous system.
Bio References	Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21. Linhoff MW, Lauren J, Cassidy RM, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61:734-49. Siddiqui TJ, Pancaroglu R, Kang Y, et al. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J. Neurosci. 2010; 30:7495-506. Haines BP and Rigby PW. Developmentally regualted expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr. Patterns 2007; 7:23-9.
Clonality	Polyclonal
Gene ID	80059
Gene Name	LRRTM4
Reactivity	H
Legend image 1	Western blot analysis of LRRTM4 in HeLa cell lysate with LRRTM4 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
Type image 1	WB
Legend image 2	Immunohistochemistry of LRRTM4 in human brain tissue with LRRTM4 antibody at 2.5 µg/mL.
Type image 2	IHC
Legend image 3	Immunofluorescence of LRRTM4 in human brain tissue with LRRTM4 antibody at 20 µg/mL.
Type image 3	IF
Other Accession	NP_001128217; 156139147
Isotype	IgG
Calculated MW	67217
Antigen Source	Homo sapiens
Target/Specificity	LRRTM4; At least two isoforms of LRRTM4 are known to exist; this antibody will both isoforms. LRRTM4 antibody is predicted to not cross-react with other LRRTM family members.
Purification	LRRTM4 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	LRRTM4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form	Liquid
Application Notes	LRRTM4 antibody can be used for detection of LRRTM4 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	HeLa Cell Lysate;
Buffer	LRRTM4 Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/4/2025

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