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SIK2 Antibody

SIK2 Antibody

Item no.	ABC-ASC11321
Manufacturer	Abcepta
Amount	100 ug
Category	Metabolism Diabetes Glucose Homeostasis Antibodies Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies Immunostaining Immunochemistry
Type	Antibody Primary
Applications	WB, IF, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Horike N, Takemori H, Katoh Y, et al. Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J. Biol. Chem. 2003; 278:18440-7. Screaton RA, Conkright MD, Katoh Y, et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 2004; 119:61-74. Muraoka M, Fukushima A, Viengchareun S, et al. Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes. Am. J. Physiol. Endocrinol. Metab. 2009; 296:E1430-9. Sasaki T, Takemori H, Yagita Y, et al. SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB. Neuron 2011; 69:106-19.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Manufacturer - Category	Primary Antibodies; Cardiovascular; Signal Transduction
Manufacturer - Targets	SIK2; SIK2 antibody is predicted to not cross-react with other SIK protein family members.
Storage Conditions	SIK2 antibody can be stored at 4? for three months and -20?, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Bio Background	SIK2 Antibody: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
Clonality	Polyclonal
Gene Name	SIK2
Reactivity	H, M, Rat
Calculated Molecular Weight	103915
Antigen Source	Homo sapiens
Purification	SIK2 Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	SIK2 antibody can be used for detection of SIK2 by Western blot at 1 µg/mL.
Positive Control	SW480 Cell Lysate
Buffer	SIK2 Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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