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ORMDL1 Antibody

ORMDL1 Antibody

Item no.	ABC-ASC11327
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IF, ELISA, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Primary Accession	Q9P0S3
Application	WB, IHC-P, IF, E
Bio Background	ORMDL1 Antibody: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.
Bio References	Hjelmqvist L, Tuson M, Marfany G, et al. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002; 3(6): RESEARCH0027 Araki W, Takahashi-Sasaki N, Chui DH, et al. A family of membrane proteins associated with Presenilin expression and α-secretase function. FASEB J. 2007; 22: 819-827 Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473 Breslow DK, Collins SR, Bodenmiller B, et al. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010; 463(7284):1048-53
Clonality	Polyclonal
Gene ID	94101
Gene Name	ORMDL1
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of ORMDL1 in SK-N-SH Cell lysate with ORMDL1 antibody at (A) 1 µg/mL and (B) 2 µg/mL.
Type image 1	WB
Legend image 2	Immunohistochemistry of ORMDL1 in mouse brain tissue with ORMDL1 antibody at 5 µg/mL.
Type image 2	IHC
Legend image 3	Immunofluorescence of ORMDL1 in mouse brain tissue with ORMDL1 antibody at 20 µg/mL.
Type image 3	IF
Other Accession	NP_057551; 189458852
Isotype	IgG
Calculated MW	17371
Antigen Source	Homo sapiens
Target/Specificity	ORMDL1; ORMDL1 antibody may cross-react with other ORMDL protein family members.
Purification	ORMDL1 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	ORMDL1 antibody can be stored at 4 ℃, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form	Liquid
Application Notes	ORMDL1 antibody can be used for detection of ORMDL1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	SK-N-SH Cell Lysate;
Buffer	ORMDL1 Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/2/2025

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