CD33 Antibody

CD33 antibody was raised against a 14 amino acid synthetic peptide near the center of human CD33.
The immunogen is located within amino acids 180 - 230 of CD33.

CD33 Antibody: CD33 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family that is highly expressed on myeloid progenitor cells. Assessment of CD33 expression is of great importance in the immunodiagnosis of acute leukemia, allowing distinction between myeloid and lymphoid origin, as CD33 is generally restricted to the myelomonocytic lineage. CD33 can associate with the protein-tyrosine phosphatases SHP-1 and SHP-2 and thus could modulate downstream signaling events associated with cell activation. Common variants of CD33 have been found to be associated with late-onset Alzheimer's disease.

CD33

39825

CD33 Antibody is affinity chromatography purified via peptide column.

CD33 antibody can be used for detection of CD33 by Western blot at 1 - 2 μ g/mL.

CD33 Antibody is supplied in PBS containing 0.02% sodium azide.