KEAP1 Antibody

KEAP1; At least two isoforms of KEAP1 are known to exist.

KEAP1 Antibody: KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-?B activity by targeting IKK? degradation. Mutation of the KEAP1 gene is found in lung cancer.

KEAP1 {ECO:0000303|PubMed:14585973, ECO:0000312|HGNC:HGNC:23177}

69666

KEAP1 Antibody is affinity chromatography purified via peptide column.

KEAP1 antibody can be used for detection of KEAP1 by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL.

KEAP1 Antibody is supplied in PBS containing 0.02% sodium azide.