FMR1 Antibody

FMR1 antibody can be used for detection of FMR1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.

FMR1; FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.

Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).

FMR1 {ECO:0000303|PubMed:8504300, ECO:0000312|HGNC:HGNC:3775}

71174

FMR1 antibody is affinity chromatography purified via peptide column.

FMR1 antibody can be used for detection of FMR1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.

FMR1 antibody is supplied in PBS containing 0.02% sodium azide.