LAMTOR1 Antibody

LAMTOR1; LAMTOR1 antibody is human, mouse and rat specific. LAMTOR1 antibody is predicted to not cross-react with other LAMTOR family proteins.

LAMTOR1 is a 161 amino acid membrane protein belonging to the LAMTOR family. It has been identified to interact with and recruit the four Rag GTPases (Rag A-D) to the surface of lysosomes (1). The mTORC1 kinase complex is a critical component in the regulation of cell growth (2). As part of the ragulator complex, LAMTOR1 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids (3). LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes / lysosomes (4).

LAMTOR1 {ECO:0000303|PubMed:31001086, ECO:0000312|HGNC:HGNC:26068}

17745

LAMTOR1 antibody is affinity chromatography purified via peptide column.

LAMTOR1 antibody can be used for detection of LAMTOR1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.

LAMTOR1 antibody is supplied in PBS containing 0.02% sodium azide.