CASR Antibody

P41180

The calcium-sensing receptor protein (CASR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule (1). It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis (1). Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism (1, 2). Recent evidence suggests that activated CASR contributes to the cytokine secretion through the partial MAPK and NF-kappaB pathways in T cells (3).

Polyclonal

CASR (HGNC:1514)

Western blot analysis of CASR in EL4 cell lysate with CASR antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.

Immunohistochemistry of CASR in human kidney tissue with CASR antibody at 5 µg/mL.

Immunofluorescence of CASR in human kidney tissue with CASR antibody at 20 µg/mL.

NP_001171536; 296010811

120675

CASR; CASR antibody is human, mouse and rat reactive. At least two isoforms of CASR are known to exist.

CASR antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.

CASR antibody can be used for detection of CASR by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.

CASR Antibody is supplied in PBS containing 0.02% sodium azide.