CRH Antibody

P06850

Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1). In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2). Marked reduction in this protein has been observed in association with Alzheimer disease (3).

Polyclonal

CRH

Western blot analysis of CRH in human placenta tissue lysate with CRH antibody at (A) 1 and (B) 2 µg/ml.

Immunohistochemistry of CRH in human brain tissue with CRH antibody at 5 µg/mL.

Immunofluorescence of CRH in human brain tissue with CRH antibody at 20 µg/mL.

NP_000747; 4503041

21422

CRH; CRH antibody is human specific.

CRH antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.

CRH antibody can be used for detection of CRH by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.

CRH antibody is supplied in PBS containing 0.02% sodium azide.