MFN2 Antibody

MFN2 antibody was raised against a 17 amino acid peptide near the center of human MFN2.
The immunogen is located within amino acids 250 - 300 of MFN2.

Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1, 2). MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3, 4). Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5).

MFN2 {ECO:0000303|PubMed:12598526, ECO:0000312|HGNC:HGNC:16877}

86402

MFN2 antibody is affinity chromatography purified via peptide column.

MFN2 antibody can be used for detection of MFN2 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for Immunohistochemistry at 5 μ g/mL. For Immunoflorescence start at 20 μ g/mL.

MFN2 antibody is supplied in PBS containing 0.02% sodium azide.