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PTPN5 Antibody

PTPN5 Antibody

Item no.	ABC-ASC11866
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Type	Antibody Primary
Applications	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	Braithwaite SP, Paul S, Nairn AC, et al. Synaptic plasticity: one STEP at a time. Trends Neurosci. 2006; 29:452-8. Paul S, Snyder GL, Yokakura H, et al. The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway. J. Neurosci. 2000; 20:5630-8. Paul S, Nairn AC, Wang P, et al. NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat. Neurosci. 2003; 6:34-42. Braithwaite SP, Adkisson M, Leung J, et al. Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP). Eur. J. Neurosci. 2006; 23:2847-56.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	PTPN5; PTPN5 antibody is human and mouse reactive.
Storage Conditions	PTPN5 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1). It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2). NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3). Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4, 5). PTPN5 may play a role in Alzheimer's disease (1).
Clonality	Polyclonal
Reactivity	H, M
Calculated Molecular Weight	Predicted: 62 kDa Observed: 60 kDa
Antigen Source	homo sapiens
Purification	PTPN5 antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	PTPN5 antibody can be used for detection of PTPN5 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Jurkat Cell Lysate
Buffer	PTPN5 antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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