FH Antibody (monoclonal) (M09)

Item no.	ABC-AT2045a
Manufacturer	Abcepta
Amount	100 ug
Category	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC, ELISA
Clone	30000000
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b Kappa
Citations	An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. Yogev O, et al. PLoS Biol, 2010 Mar 9. PMID 20231875.UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Yang Y, et al. Cancer Genet Cytogenet, 2010 Jan 1. PMID 19963135.Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. McCauley JL, et al. Genes Immun, 2009 Oct. PMID 19626040.Novel role of fumarate metabolism in dahl-salt sensitive hypertension. Tian Z, et al. Hypertension, 2009 Aug. PMID 19546378.
NCBI	NP_000134.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Fumarate hydratase,mitochondrial,Fumarase,FH
Similar products	Fumarase, FH, mitochondrial, Fumarate hydratase
Available
Manufacturer - Targets	FH (AAH03108, 33 a.a. ~ 510 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
Clonality	Monoclonal
Gene Name	FH {ECO:0000303\|PubMed:27037871, ECO:0000312\|HGNC:HGNC:3700}
Subtitle	Mouse monoclonal antibody raised against a full length recombinant FH.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	0.5mg/ml
Dilution	WB: 1:500~1000 WB: 1:500~1000 IHC E
Org Accession	AAH03108
Gene Description	fumarate hydratase
Gene Summary	The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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