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GFRA1 Antibody (monoclonal) (M03)

GFRA1 Antibody (monoclonal) (M03)

Item no.	ABC-AT2194a
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Western Blot Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB
Clone	30000
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	[Multiple endocrine neoplasia: genetic aspects] Calender A, et al. Bull Acad Natl Med, 2010 Jan. PMID 20669561.L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. Yokoyama K, et al. Nephron Clin Pract, 2010. PMID 20424473.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Expression of GDNF receptors GFRalpha1 and RET is preserved in substantia nigra pars compacta of aging Asian Indians. Alladi PA, et al. J Chem Neuroanat, 2010 Sep. PMID 20347960.Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response. Souza RP, et al. J Psychiatr Res, 2010 Aug. PMID 20116071.
NCBI	NP_001138925.1,NP_005255.1,NP_665736.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	GDNF family receptor alpha-1,GDNF receptor alpha-1,GDNFR-alpha-1,GFR-alpha-1,RET ligand 1,TGF-beta-related neurotrophic factor receptor 1,GFRA1,GDNFRA,RETL1,TRNR1
Similar products	GFR-alpha-1, GFRA1, RET ligand 1, GDNFRA, RETL1, TRNR1, GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, TGF-beta-related neurotrophic factor receptor 1
Available
Manufacturer - Targets	GFRA1 (NP_005255, 32 a.a. ~ 119 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
Clonality	Monoclonal
Gene Name	GFRA1
Subtitle	Mouse monoclonal antibody raised against a full length recombinant GFRA1.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 WB: 1:500~1000
Org Accession	NP_005255
Gene Description	GDNF family receptor alpha 1
Gene Summary	Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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