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HES1 Antibody (monoclonal) (M02)

HES1 Antibody (monoclonal) (M02)

Item no.	ABC-AT2355a
Manufacturer	Abcepta
Amount	100 ug
Category	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF
Clone	3A3
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG2b Kappa
Citations	The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study. Wang X, et al. J Cancer Res Clin Oncol, 2010 Jul. PMID 20091184.Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Sang L, et al. Trends Mol Med, 2010 Jan. PMID 20022559.Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness. Coad RA, et al. Biochem Cell Biol, 2009 Dec. PMID 19935883.Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. Hartman J, et al. Breast Cancer Res, 2009. PMID 19891787.Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1. Maddodi N, et al. J Biol Chem, 2010 Jan 1. PMID 19880519.
NCBI	NP_005515.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Transcription factor HES-1,Class B basic helix-loop-helix protein 39,bHLHb39,Hairy and enhancer of split 1,Hairy homolog,Hairy-like protein,hHL,HES1,BHLHB39,HL,HRY
Similar products	HES1, BHLHB39, HL, HRY, Transcription factor HES-1, Class B basic helix-loop-helix protein 39, Hairy and enhancer of split 1, Hairy homolog, Hairy-like protein, bHLHb39, hHL
Available
Manufacturer - Targets	HES1 (NP_005515, 36 a.a. ~ 142 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Clonality	Monoclonal
Gene Name	HES1
Subtitle	Mouse monoclonal antibody raised against a partial recombinant HES1.
Reactivity	H, Rat
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	IF WB: 1:500~1000
Org Accession	NP_005515
Gene Description	hairy and enhancer of split 1, (Drosophila)
Gene Summary	This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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