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IL10 Antibody (monoclonal) (M03)

IL10 Antibody (monoclonal) (M03)

Item no.	ABC-AT2500a
Manufacturer	Abcepta
Amount	50 ug
Category	Neuroscience Neuroinflammation Antibodies Cell Biology Cell Culture Cytokines Western Blot Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB
Clone	1C10
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG3 Kappa
Citations	Association of Interleukin-10 Polymorphisms with Cytokines in Type 2 Diabetic Nephropathy. Kung WJ, et al. Diabetes Technol Ther, 2010 Sep 1. PMID 20809684.Interleukin-10 microsatellite variants and the risk of acute coronary syndrome among Tunisians. Ben-Hadj-Khalifa-Kechiche S, et al. Int J Immunogenet, 2010 Aug 29. PMID 20807264.Intereleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution. Arosio B, et al. Int J Alzheimers Dis, 2010 Jul 20. PMID 20798845.The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk. Yu KD, et al. Breast Cancer Res Treat, 2010 Aug 25. PMID 20737205.Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese. Liu J, et al. BMC Cancer, 2010 Aug 24. PMID 20735825.
NCBI	NP_000563.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Interleukin-10,IL-10,Cytokine synthesis inhibitory factor,CSIF,IL10
Similar products	IL-10, IL10, Interleukin-10, Cytokine synthesis inhibitory factor, CSIF
Available
Manufacturer - Targets	IL10 (AAI04253.1, 74 a.a. ~ 178 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Clonality	Monoclonal
Gene Name	IL10
Subtitle	Mouse monoclonal antibody raised against a partial recombinant IL10.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 WB: 1:500~1000
Org Accession	AAI04253.1
Gene Description	interleukin 10
Gene Summary	The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 1/1/2026

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