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IL27 Antibody (monoclonal) (M01)

IL27 Antibody (monoclonal) (M01)

Item no.	ABC-AT2518a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Cell Biology Cell Culture Cytokines Immunoprecipitation Western Blot Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IP
Clone	3F12
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes. Morishima N, et al. J Biomed Biotechnol, 2010. PMID 20454646.Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1. Zhang J, et al. J Biol Chem, 2010 Jul 9. PMID 20435892.Cytokines involved in interferon-gamma production by human macrophages. Robinson CM, et al. J Innate Immun, 2009 Dec. PMID 20375623.Activation of human bronchial epithelial cells by inflammatory cytokines IL-27 and TNF-alpha: implications for immunopathophysiology of airway inflammation. Cao J, et al. J Cell Physiol, 2010 Jun. PMID 20301193.
NCBI	NP_663634.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Interleukin-27 subunit alpha,IL-27 subunit alpha,IL-27-A,IL27-A,Interleukin-30,p28,IL27,IL27A,IL30
Similar products	IL27, IL27A, Interleukin-27 subunit alpha, p28, IL30, IL-27 subunit alpha, IL-27-A, IL27-A, Interleukin-30
Available
Manufacturer - Targets	IL27 (NP_663634, 177 a.a. ~ 243 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
Clonality	Monoclonal
Gene Name	IL27
Subtitle	Mouse monoclonal antibody raised against a partial recombinant IL27.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	IP WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000
Org Accession	NP_663634
Gene Description	interleukin 27
Gene Summary	The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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