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IRF4 Antibody (monoclonal) (M02)

IRF4 Antibody (monoclonal) (M02)

Item no.	ABC-AT2544a
Manufacturer	Abcepta
Amount	100 ug
Category	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies By Cell Type Hematology Leukemia Lymphoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC, ELISA
Clone	2F2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Staudt V, et al. Immunity, 2010 Aug 27. PMID 20674401.Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom. Newton-Bishop JA, et al. Cancer Epidemiol Biomarkers Prev, 2010 Aug. PMID 20647408.IRF4 variants have age-specific effects on nevus count and predispose to melanoma. Duffy DL, et al. Am J Hum Genet, 2010 Jul 9. PMID 20602913.Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. Ucisik-Akkaya E, et al. Mol Hum Reprod, 2010 Oct. PMID 20587610.Web-based, participant-driven studies yield novel genetic associations for common traits. Eriksson N, et al. PLoS Genet, 2010 Jun 24. PMID 20585627.
NCBI	NP_001182215.1,NP_002451.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Interferon regulatory factor 4,IRF-4,Lymphocyte-specific interferon regulatory factor,LSIRF,Multiple myeloma oncogene 1,NF-EM5,IRF4,MUM1
Similar products	IRF4, IRF-4, MUM1, Interferon regulatory factor 4, Lymphocyte-specific interferon regulatory factor, Multiple myeloma oncogene 1, NF-EM5, LSIRF
Available
Manufacturer - Targets	IRF4 (NP_002451, 342 a.a. ~ 451 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6; 14)(p25; q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
Clonality	Monoclonal
Gene Name	IRF4
Subtitle	Mouse monoclonal antibody raised against a partial recombinant IRF4.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 WB: 1:500~1000 IHC E
Org Accession	NP_002451
Gene Description	interferon regulatory factor 4
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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