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KRAS Antibody (monoclonal) (M01)

KRAS Antibody (monoclonal) (M01)

Item no.	ABC-AT2650a
Manufacturer	Abcepta
Amount	100 ug
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Adenocarcinoma Cytoskeleton Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Lung Cancer Colorectal Cancer Immunostaining small GTPases Ras Subfamily
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, ELISA
Clone	S2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	1.Evidence for aldosterone-dependent growth of renal cell carcinoma.King S, Bray S, Galbraith S, Christie L, Fleming SInt J Exp Pathol. 2014 May 7. doi: 10.1111/iep.12074.2.KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy.Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, Dimartino V, Hobor S, Jacobs B, Ercolani C, Lamba S, Scala E, Veronese S, Laurent-Puig P, Siena S, Tejpar S, Mottolese M, Punt CJ, Gambacorta M, Bardelli A, Di Nicolantonio FInt J Cancer. 2013 Feb 12. doi: 10.1002/ijc.28106.3.Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.Fuentes-Calvo I, Blazquez-Medela AM, Santos E, Lopez-Novoa JM, Martinez-Salgado C.PLoS One. 2010 Jan 14;5(1):e8703.
NCBI	NP_004976.2,NP_203524.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	GTPase KRas,K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras,GTPase KRas,N-terminally processed,KRAS,KRAS2,RASK2
Similar products	KRAS, N-terminally processed, KRAS2, RASK2, GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras
Available
Manufacturer - Targets	KRAS (AAH13572, 1 a.a. ~ 188 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
Clonality	Monoclonal
Gene Name	KRAS
Subtitle	Mouse monoclonal antibody raised against a full length recombinant KRAS.
Reactivity	H
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	0.5 mg/ml
Dilution	IF WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	AAH13572
Gene Description	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Gene Summary	This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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