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MFN1 Antibody (monoclonal) (M04)

MFN1 Antibody (monoclonal) (M04)

Item no.	ABC-AT2850a
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Neural Mitochondrial Function Molecular Targets for Neuroscience Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ELISA
Clone	3C9
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	1.A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.Yue W, Chen Z, Liu H, Yan C, Chen M, Feng D, Yan C, Wu H, Du L, Wang Y, Liu J, Huang X, Xia L, Liu L, Wang X, Jin H, Wang J, Song Z, Hao X, Chen QCell Res. 2014 Feb 11. doi: 10.1038/cr.2014.20.2.Phosphatidic Acid (PA)-Preferring Phospholipase A1 Regulates Mitochondrial Dynamics.Baba T, Kashiwagi Y, Arimitsu N, Kogure T, Edo A, Maruyama T, Nakao K, Nakanishi H, Kinoshita M, Frohman MA, Yamamoto A, Tani KJ Biol Chem. 2014 Mar 5.3.Extramitochondrial OPA1 and adrenocortical function.Fulop L, Rajki A, Katona D, Szanda G, Spat AMol Cell Endocrinol. 2013 Jul 29. pii: S0303-7207(13)00315-8. doi: 10.1016/j.mce.2013.07.021.4.Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c.Ban-Ishihara R, Ishihara T, Sasaki N, Mihara K, Ishihara NProc Natl Acad Sci U S A. 2013 Jul 16;110(29):11863-8. doi: 10.1073/pnas.1301951110. Epub 2013 Jul 2.5.Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short term endurance training.Russell AP, Lamon S, Boon H, Wada S, Guller I, Brown EL, Chibalin AV, Zierath J, Snow RJ, Stepto NK, Wadley GD, Akimoto TJ Physiol. 2013 Jun 24.6.Atad3 Function Is Essential for Early Post-Implantation Development in the Mouse.Goller T, Seibold UK, Kremmer E, Voos W, Kolanus W.PLoS One. 2013;8(1):e54799. doi: 10.1371/journal.pone.0054799. Epub 2013 Jan 25.7.TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression.Takamura H, Koyama Y, Matsuzaki S, Yamada K, Hattori T, Miyata S, Takemoto K, Tohyama M, Katayama T.PLoS One. 2012;7(12):e51912. doi: 10.1371/journal.pone.0051912. Epub 2012 Dec 20.8.PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy.Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N.Sci Rep. 2012;2:1002. doi: 10.1038/srep01002. Epub 2012 Dec 19.9.Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation.Lin HY, Lai RH, Lin ST, Lin RC, Wang MJ, Lin CC, Lee HC, Wang FF, Chen JY.Cell Death Differ. 2013 Jan;20(1):139-53. doi: 10.1038/cdd.2012.106. Epub 2012 Sep 7.10.Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties.Bui M, Gilady SY, Fitzsimmons RE, Benson MD, Lynes EM, Gesson K, Alto NM, Strack S, Scott JD, Simmen T.J Biol Chem. 2010 Oct 8;285(41):31590-602. Epub 2010 Jul 29.11.PGC1{alpha} relationship with skeletal muscle palmitate oxidation is not present with obesity, despite maintained ained PGC1{alpha} and PGC1{beta} protein.Holloway GP, Perry CG, Thrush AB, Heigenhauser GJ, Dyck DJ, Bonen A, Spriet LL.Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1060-9. Epub 2008 Mar 18.12.OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.Zanna C, Ghelli A, Porcelli AM, Karbowski M, Youle RJ, Schimpf S, Wissinger B, Pinti M, Cossarizza A, Vidoni S, Valentino ML, Rugolo M, Carelli V.Brain. 2008 Feb; 131(Pt 2): 352-67.
NCBI	NP_284941.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Mitofusin-1,365-,Fzo homolog,Transmembrane GTPase MFN1,MFN1
Similar products	Mitofusin-1, MFN1, Fzo homolog, Transmembrane GTPase MFN1, 365-
Available
Manufacturer - Targets	MFN1 (AAH40557, 1 a.a. ~ 741 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
Clonality	Monoclonal
Gene Name	MFN1
Subtitle	Mouse monoclonal antibody raised against a full length recombinant MFN1.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	AAH40557
Gene Description	mitofusin 1
Gene Summary	The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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