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NBR1 Antibody (monoclonal) (M01)

NBR1 Antibody (monoclonal) (M01)

Item no.	ABC-AT2977a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Cell Biology Cell Status Western Blot ELISA Autophagy Primary Antibodies Immunostaining
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ELISA
Clone	6B11
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	1.Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease.Rue L, Lopez-Soop G, Gelpi E, Martinez-Vicente M, Alberch J, Perez-Navarro E.Neurobiol Dis. 2013 Jan 4. pii: S0969-9961(12)00400-7. doi: 10.1016/j.nbd.2012.12.008.2.NBR1 acts as an autophagy receptor for peroxisomes.Deosaran E, Larsen KB, Hua R, Sargent G, Wang Y, Kim S, Lamark T, Jauregui M, Law K, Lippincott-Schwartz J, Brech A, Johansen T, Kim PKJ Cell Sci. 2013 Feb 15;126(Pt 4):939-52. doi: 10.1242/jcs.114819. Epub 2012 Dec 13.3.Molecular determinants of selective clearance of protein inclusions by autophagy.Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM.Nat Commun. 2012 Dec 4;3:1240. doi: 10.1038/ncomms2244.4.Nbr1 is a novel inhibitor of ligand-mediated RTK degradation.Mardakheh FK, Auciello G, Dafforn TR, Rappoport JZ, Heath JK.Mol Cell Biol. 2010 Oct 11. [Epub ahead of print]5.Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.Mardakheh FK, Yekezare M, Machesky LM, Heath JK.J Cell Biol. 2009 Oct 12. [Epub ahead of print]
NCBI	NP_005890.2,NP_114064.1,NP_114068.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Next to BRCA1 gene 1 protein,Cell migration-inducing gene 19 protein,Membrane component chromosome 17 surface marker 2,Neighbor of BRCA1 gene 1 protein,Protein 1A1-3B,NBR1,1A13B,KIAA0049,M17S2
Similar products	NBR1, KIAA0049, M17S2, Next to BRCA1 gene 1 protein, 1A13B, Cell migration-inducing gene 19 protein, Membrane component chromosome 17 surface marker 2, Neighbor of BRCA1 gene 1 protein, Protein 1A1-3B
Available
Manufacturer - Targets	NBR1 (NP_005890, 2 a.a. ~ 96 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.
Clonality	Monoclonal
Gene Name	NBR1
Subtitle	Mouse monoclonal antibody raised against a partial recombinant NBR1.
Reactivity	H
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Concentration	1mg/ml
Dilution	WB: 1:500~1000 E
Org Accession	NP_005890
Gene Description	neighbor of BRCA1 gene 1
Gene Summary	The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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