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NCOA4 Antibody (monoclonal) (M05)

NCOA4 Antibody (monoclonal) (M05)

Item no.	ABC-AT2983a
Manufacturer	Abcepta
Amount	100 ug
Category	Oncology Antibodies By Cell Type Carcinoma Cell Biology Adenocarcinoma Cytoskeleton Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining small GTPases Rho Subfamily
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, IHC, ELISA
Clone	1F11
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Lambda
Citations	Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas. Sadow PM, et al. Endocr Pathol, 2010 Jun. PMID 20012784.The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa I, et al. PLoS Genet, 2009 Sep. PMID 19730683.Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins. Richardson DS, et al. Cancer Res, 2009 Jun 1. PMID 19487296.Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Lu Y, et al. J Lipid Res, 2008 Dec. PMID 18660489.Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Peng Y, et al. Am J Pathol, 2008 Jan. PMID 18156210.
NCBI	NP_001138732.1,NP_001138733.1,NP_001138734.1,NP_001138735.1,NP_005428.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Nuclear receptor coactivator 4,NCoA-4,Androgen receptor coactivator 70 kDa protein,70 kDa AR-activator,70 kDa androgen receptor coactivator,Androgen receptor-associated protein of 70 kDa,Ret-activating protein ELE1,NCOA4,ARA70,ELE1,RFG
Similar products	NCOA4, ARA70, ELE1, RFG, Nuclear receptor coactivator 4, Androgen receptor coactivator 70 kDa protein, Androgen receptor-associated protein of 70 kDa, Ret-activating protein ELE1, NCoA-4, 70 kDa AR-activator, 70 kDa androgen receptor coactivator
Available
Manufacturer - Targets	NCOA4 (NP_005428, 505 a.a. ~ 614 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
Clonality	Monoclonal
Gene Name	NCOA4
Subtitle	Mouse monoclonal antibody raised against a partial recombinant NCOA4.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	IF WB: 1:500~1000 WB: 1:500~1000 IHC E
Org Accession	NP_005428
Gene Description	nuclear receptor coactivator 4
Gene Summary	This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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