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NEFH Antibody (monoclonal) (M01)

NEFH Antibody (monoclonal) (M01)

Item no.	ABC-AT3010a
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Antibodies Western Blot ELISA Primary Antibodies Immunostaining Neurodegeneration Markers Glial Cell Markers
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ELISA
Clone	200000000
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	A genome-wide association study of carotid atherosclerosis in HIV-infected men. Shrestha S, et al. AIDS, 2010 Feb 20. PMID 20009918.Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders. Alberti C, et al. AIDS Res Hum Retroviruses, 2009 Aug. PMID 19678766.Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON). Guy J, et al. Mol Vis, 2008. PMID 19104679.Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. Greg?rio SP, et al. Psychiatry Res, 2009 Jan 30. PMID 19054571.Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. Rudrabhatla P, et al. J Biol Chem, 2008 Sep 26. PMID 18635547.
NCBI	NP_066554.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Neurofilament heavy polypeptide,NF-H,200 kDa neurofilament protein,Neurofilament triplet H protein,NEFH,KIAA0845,NFH
Similar products	NF-H, NEFH, Neurofilament heavy polypeptide, Neurofilament triplet H protein, 200 kDa neurofilament protein, KIAA0845, NFH
Available
Manufacturer - Targets	NEFH (NP_066554, 263 a.a. ~ 363 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
Clonality	Monoclonal
Gene Name	NEFH
Subtitle	Mouse monoclonal antibody raised against a partial recombinant NEFH.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 WB: 1:500~1000 E
Org Accession	NP_066554
Gene Description	neurofilament, heavy polypeptide
Gene Summary	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 3/5/2026

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