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PIN1 Antibody (monoclonal) (M01)

PIN1 Antibody (monoclonal) (M01)

Item no.	ABC-AT3312a
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Western Blot Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB
Clone	2F2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b Kappa
Citations	A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease. Ma SL, et al. Neurobiol Aging, 2010 Jun 24. PMID 20580132.Uncoating of human immunodeficiency virus type 1 requires prolyl isomerase Pin1. Misumi S, et al. J Biol Chem, 2010 Aug 13. PMID 20529865.The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer. Namgoong GM, et al. J Biol Chem, 2010 Jul 30. PMID 20479004.Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML. Pulikkan JA, et al. Leukemia, 2010 May. PMID 20376080.Membrane permeable cyclic peptidyl inhibitors against human Peptidylprolyl Isomerase Pin1. Liu T, et al. J Med Chem, 2010 Mar 25. PMID 20180533.
NCBI	NP_006212.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1,Peptidyl-prolyl cis-trans isomerase Pin1,PPIase Pin1,Rotamase Pin1,PIN1
Similar products	PIN1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1, Rotamase Pin1, PPIase Pin1
Available
Manufacturer - Targets	PIN1 (AAH02899, 64 a.a. ~ 163 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	Peptidyl-prolyl cis/trans isomerases (PPIases; EC 5.2.1.8), such as PIN1, catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. PIN1 is the only PPIase that specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. PIN1-catalyzed conformational regulation has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, germ cell development, neuronal differentiation, and survival (review by Lu and Zhou, 2007 [PubMed 17878917]).
Clonality	Monoclonal
Gene Name	PIN1
Subtitle	Mouse monoclonal antibody raised against a partial recombinant PIN1.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 WB: 1:500~1000
Org Accession	AAH02899
Gene Description	peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Gene Summary	The human PIN1 gene encodes an essential nuclear peptidylprolyl cis-trans isomerase (PPIase; EC 5.2.1.8) involved in regulation of mitosis. PIN1 belongs to a class of PPIases that includes the E. coli parvulin, yeast Ess1, and Drosophila dodo (dod) gene products (Lu et al., 1996 [PubMed 8606777]).[supplied by OMIM
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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