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PLP1 Antibody (monoclonal) (M05)

PLP1 Antibody (monoclonal) (M05)

Item no.	ABC-AT3346a
Manufacturer	Abcepta
Amount	100 ug
Category	Neuroscience Neural Lineage Markers Antibodies Western Blot ELISA Primary Antibodies Immunostaining Neuronal Cell Markers
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, ELISA
Clone	4H8
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Developmental and degenerative features in a complicated spastic paraplegia. Manzini MC, et al. Ann Neurol, 2010 Apr. PMID 20437587.Magnetic resonance imaging of a unique mutation in a family with Pelizaeus-Merzbacher disease. Miller E, et al. Am J Med Genet A, 2010 Mar. PMID 20186781.Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene. Sarret C, et al. Neuroscience, 2010 Mar 17. PMID 20036320.Hereditary spastic paraplegia caused by the PLP1 'rumpshaker mutation'. Svenstrup K, et al. J Neurol Neurosurg Psychiatry, 2010 Jun. PMID 19955111.Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein. Roboti P, et al. J Cell Sci, 2009 Nov 1. PMID 19825935.
NCBI	NP_000524.3,NP_001122306.1,NP_955772.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Myelin proteolipid protein,PLP,Lipophilin,PLP1,PLP
Similar products	PLP1, Myelin proteolipid protein, Lipophilin, PLP
Available
Manufacturer - Targets	PLP1 (NP_000524, 177 a.a. ~ 232 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Bio Background	This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
Clonality	Monoclonal
Gene Name	PLP1
Subtitle	Mouse monoclonal antibody raised against a partial recombinant PLP1.
Reactivity	H
Antigen Source	Human: ~~ Positive
Formulation	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Dilution	WB: 1:500~1000 E
Org Accession	NP_000524
Gene Description	proteolipid protein 1
Gene Summary	This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/1/2026

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