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RNF2 Antibody (monoclonal) (M01)

RNF2 Antibody (monoclonal) (M01)

Item no.	ABC-AT3672a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, ELISA
Clone	6C2
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	BAP1, RNF2, DING, HIPI3, RING1B, E3 ubiquitin-protein ligase RING2, HIP2-interacting protein 3, Huntingtin-interacting protein 2-interacting protein 3, Protein DinG, RING finger protein BAP-1, RING1b, 632-, RING finger protein 1B, RING finger protein 2
Available
Primary Accession	Q99496
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.
Bio References	1.Scmh1 Has E3 Ubiquitin Ligase Activity for Geminin and Histone H2A and Regulates Geminin Stability Directly or Indirectly via Transcriptional Repression of Hoxa9 and Hoxb4.Yasunaga S, Ohtsubo M, Ohno Y, Saeki K, Kurogi T, Tanaka-Okamoto M, Ishizaki H, Shirai M, Mihara K, Brock HW, Miyoshi J, Takihara Y.Mol Cell Biol. 2013 Feb; 33(4):644-60. doi: 10.1128/MCB.00974-12.2.Inaugural Article: Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo.Rugg-Gunn PJ, Cox BJ, Ralston A, Rossant J.Proc Natl Acad Sci U S A. 2010 May 17. [Epub ahead of print]3.Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.Ohtsubo M, Yasunaga S, Ohno Y, Tsumura M, Okada S, Ishikawa N, Shirao K, Kikuchi A, Nishitani H, Kobayashi M, Takihara Y.Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10396-401. Epub 2008 Jul 23.
Clonality	Monoclonal
Gene ID	6045
Gene Name	RNF2
Subtitle	Mouse monoclonal antibody raised against a partial recombinant RNF2.
Reactivity	H, M
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	RNF2 monoclonal antibody (M01), clone 6C2. Western Blot analysis of RNF2 expression in Raw 264.7 ( (Cat # AT3672a )
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	RNF2 monoclonal antibody (M01), clone 6C2 Western Blot analysis of RNF2 expression in NIH/3T3 ( (Cat # AT3672a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Western Blot analysis of RNF2 expression in transfected 293T cell line by RNF2 monoclonal antibody (M01), clone 6C2. Lane 1: RNF2 transfected lysate(37.7 KDa). Lane 2: Non-transfected lysate.
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Western blot analysis of RNF2 over-expressed 293 cell line, cotransfected with RNF2 Validated Chimera RNAi ( (Cat # AT3672a )
Type image 5	WB
Dilution image 5	1:500~1000
Legend image 6	Detection limit for recombinant GST tagged RNF2 is approximately 0.03ng/ml as a capture antibody.
Type image 6	E
Other Accession	NM_007212
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	RNF2 (NP_009143, 192 a.a. ~ 290 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_009143.1
	Clone: 6C2
Org Accession	NP_009143
Concentration	0.5 mg/ml
Gene Description	ring finger protein 2
Gene Summary	Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/4/2025

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