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TTK Antibody (monoclonal) (M02)

TTK Antibody (monoclonal) (M02)

Item no.	ABC-AT4391a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, ELISA
Clone	4G9
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TTK, MPS1, MPS1L1, Dual specificity protein kinase TTK, Phosphotyrosine picked threonine-protein kinase, PYT
Available
Primary Accession	P33981
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.
Bio References	Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. Maciejowski J, et al. J Cell Biol, 2010 Jul 12. PMID 20624902.Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. Santaguida S, et al. J Cell Biol, 2010 Jul 12. PMID 20624901.Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. Hewitt L, et al. J Cell Biol, 2010 Jul 12. PMID 20624899.A chemical tool box defines mitotic and interphase roles for Mps1 kinase. Lan W, et al. J Cell Biol, 2010 Jul 12. PMID 20624898.Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2010 May 28. PMID 20508983.
Clonality	Monoclonal
Gene ID	7272
Gene Name	TTK
Subtitle	Mouse monoclonal antibody raised against a partial recombinant TTK.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (44.99 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	TTK monoclonal antibody (M02), clone 4G9 Western Blot analysis of TTK expression in Jurkat ( (Cat # AT4391a )
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Detection limit for recombinant GST tagged TTK is approximately 0.3ng/ml as a capture antibody.
Type image 3	E
Other Accession	BC000633
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	TTK (AAH00633, 1 a.a. ~ 176 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001160163.1; NP_003309.2
	Clone: 4G9
Org Accession	AAH00633
Gene Description	TTK protein kinase

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 11/6/2025

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