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TYK2 Antibody (monoclonal) (M01)

TYK2 Antibody (monoclonal) (M01)

Item no.	ABC-AT4423a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applications	WB, IF, IP, IHC
Clone	6G12
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TYK2, Non-receptor tyrosine-protein kinase TYK2
Available
Primary Accession	P29597
Antigen Type	Recombinant Protein
Application	WB, IHC, IF, IP
Bio Background	This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Bio References	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. Chrencik JE, et al. J Mol Biol, 2010 Jul 16. PMID 20478313.Polymorphisms in innate immunity genes and risk of childhood leukemia. Han S, et al. Hum Immunol, 2010 Jul. PMID 20438785.
Clonality	Monoclonal
Gene ID	7297
Gene Name	TYK2
Subtitle	Mouse monoclonal antibody raised against a partial recombinant TYK2.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to TYK2 on HeLa cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Immunoprecipitation of TYK2 transfected lysate using anti-TYK2 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with TYK2 MaxPab rabbit polyclonal antibody.
Type image 2	IP
Legend image 3	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.41 KDa) .
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	TYK2 monoclonal antibody (M01), clone 6G12 Western Blot analysis of TYK2 expression in HeLa ( (Cat # AT4423a )
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	Western Blot analysis of TYK2 expression in transfected 293T cell line by TYK2 monoclonal antibody (M01), clone 6G12. Lane 1: TYK2 transfected lysate(133.7 KDa). Lane 2: Non-transfected lysate.
Type image 5	WB
Dilution image 5	1:500~1000
Legend image 6	Immunoperoxidase of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]
Type image 6	IHC
Other Accession	BC014243
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	TYK2 (AAH14243, 276 a.a. ~ 375 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_003322.3
	Clone: 6G12
Org Accession	AAH14243
Gene Description	tyrosine kinase 2
Gene Summary	This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/2/2025

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