SARS-CoV-2 Trimeric Spike 1 Protein Antibody

Primary Antibodies

Unconjugated

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Trimeric Spike 1 Protein Antibody is a Mouse Monoclonal Antibody against SARS-CoV-2/COVID-19 Trimeric S1 Protein.

The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the S1 and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.

This antibody is designed to work with saliva patient samples that do not require lysis. It is recommended to use abx024240 as the capture antibody and abx024241 (this antibody) as the detection antibody. In an ELISA with TMB substrate, this pair can detect SARS-CoV-2 trimeric spike protein with a sensitivity of approximately 300 pg/ml.

PBS, pH 7.4. Does not contain preservatives.

This product is for research use only.

Binds to recombinant SARS-CoV-2 trimeric spike protein. Recognizes the membrane bound form from the cell line expressing full-length SARS-CoV-2 protein. This antibody is specific to SARS-CoV-2 Spike trimeric protein and does not cross-react with recombinant SARS-CoV, HCoV-229E, HCoV-HKU1, HCoV-NL63 and HCoV-OC43.