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PD-L1 Recombinant Antibody AE00385

PD-L1 Recombinant Antibody AE00385

Item no.	AE00385-1mg-A
Manufacturer	Aeonian Biotech
Amount	1mg
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal, recombinant
Applications	IHC
Clone	AE711R
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG kappa
Formula	0.2 mg IgG/ml in PBS with 0.05% BSA & 0.05% azide.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	B7 homolog 1; CD_antigen: CD274; Programmed cell death 1 ligand 1; Programmed death ligand 1; B7-H; B7H1; B7-H1; CD274; PD-L1; PDCD1L1; PDCD1LG1; PDL1; PDCD1 ligand 1
Available
Description	Specific, and tissue microarray-validated rabbit recombinant antibody clone AE711R to human PD-L1
Principle name	PD-L1
immunogen	KLH-conjugated peptide, its sequence is proprietary
purification method	By Protein A from bioreactor concentrate
Cell. Localization	plasma membrane
Positive controls	anaplastic large cell lymphoma, colorectal adenocarcinoma, follicular thyroid carcinoma
RRID	AB_2924905
IHC comments	AE00385 to PD-L1 was successfully used to stain plasma membranes in sections of colorectal adenocarcinoma, anaplastic large cell lymphoma, and of follicular thyroid carcinoma. Recommended concentration: 1-3 μg/ml
Tissue Microarray Validation (Normal tissue)	strong positive: lung; ovary corpus luteum; placenta early; placenta mature; thymus \| weak to moderate: appendix mucosa; duodenum mucosa; ileum mucosa; lymph node; pituitary gland anterior lobe; pituitary gland posterior lobe; spleen; tonsil \| no staining at all: adipose; adrenal gland; aorta media; appendix muscular wall; bone marrow; breast; bronchus mucosa; cerebellum; cerebrum; colon mucosa; colon muscular wall; duodenum Brunner gland; ectocervix; endocervix; endometrium, proliferation; endometrium, secretion; epididymis; esophagus squamous epithelium; fallopian tube; gallbladder; heart muscle; liver; myometrium; ovarian stroma; pancreas; parathyroid gland; parotid gland; prostate; rectum mucosa; renal cortex; renal medulla; seminal vesicle; sinus paranasalis; skin ; stomach; testis; thyroid gland; urinary bladder muscular wall; urothelium
Tissue Microarray Validation (Cancer tissue)	strong positive: Tumor cells: anaplastic large cell lymphoma; colorectal adenocarcinoma; follicular thyroid carcinoma; gastrointestinal stromal tumor; prostate adenocarcinoma; Tumor-associated immune cells: basal cell carcinoma; breast cancer no special type; mucinous ovarian carcinoma; urothelial carcinoma invasive \| weak to moderate: clear cell renal cell carcinoma; non-invasive papillary urothelial carcinoma; vulva squamous cell carcinoma \| no staining at all:
Expiration	Integrity warranted for 24 months after purchase when handled and stored according to instructions, see below.
Storage	Avoid repeated freeze/thaw cycles. For long term storage, keep small aliquots at -20°C or -80°C and keep one aliquot at 4°C for daily experimentations. Azide will preserve antibody at 4°C for 6-12 months, when kept away from direct sun light.
Warranty	This product is only warranted for the specifications as described in this product sheet and only when the product is handled and stored according to instructions. User should validate this antibody in the application and tissue/cell type as required, after confirmation of integrity upon receipt is obtained by reproducing the performance as described below. Should such confirmation not be attempted, any warranty is void. In case of non-conformance, user needs to contact us immediately for replacement or refund.
Liability	This product is for in vitro research use only. Any other applications, such as diagnostics or therapeutics, or in vivo experiments, and the validation of this product therein, are solely at the responsibility of the buyer/user.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

AE00385-1mg-A-datasheet.pdf

AE00385-1mg-A-safety-datasheet.pdf