Janus Kinase 2 (JAK2), anti-human

Rabbit anti-Human Janus kinase 2 (JAK2), polyclonal antibody.

A synthetic peptide derived from the human JAK2 peptide, conjugated with KLH for immunization

Protein G affinity purified

Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase that plays an important role in signal transduction through its association with receptors on the cell membrane. When these receptors are activated by extracellular signals, the receptors activate JAK2 which in turn phosphorylates the tyrosine residues on the receptors. The phosphorylation enables the binding of downstream signaling molecules, primarily, signal transducer and activator of transcription (STAT) proteins. STATs possess a SH-domain that specifically binds to phosphorylated tyrosine residue on the receptor. STAT in cytoplasma is activated after binding and migrates to nucleus to activate gene transcription. JAK2 mediates the transduction of a variety of extra-cellular signals in this pattern. The receptors that are associated with JAK2 include type II cytokine receptors, GM-CSF receptor family, gp130 receptor family, growth hormone receptor, prolactin receptor and EPO receptor.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Life science research, stem cell factor signalling, cancer research