Tumor Necrosis Factor alpha (TNF-a) (**Biotin Labeled)

Human TNF-alpha

This antibody recognizes both natural and recombinant human TNF-alpha.

Human, other species not tested

Tumor Necrosis Factor alpha (TNF-alpha) is a multifunctional pro-inflammatory cytokine, mainly secreted by activated macrophages. TNF-alpha was named for its remarkable ability to cause hemorrhagic necrosis of tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. The pleiotropic attribute of TNF-alpha regulation is associated with its ability to trigger multiple signalling pathways simultaneously. It is well documented that TNF-alpha functions through its receptors, TNFR1 (p55) and TNFR2 (p75).
TNF-alpha not only contributes to the immune response to bacterial, fungal, viral and parasitic invasions, but also functions in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. TNF-alpha hyper-expression in response to some bacterial components such as LPS can cause life threatening septic shock. Recombinant TNF-alpha, in combination with chemotherapy, has been applied for treatment of soft sarcomas, melanomas and other irresectable tumors. Anti-TNF-alpha therapy has been used for treatment of rheumatoid arthritis.

ELISA: In combination with capture antibody CH8820 (Cat. No.: MO-C40003B) and avidin-HRP conjugate, this biotin-conjugated monoclonal antibody can be used as a tracer antibody in sandwich ELISA applications for human TNF-alpha detection.

Store at -20C